Among many African-Americans, the idea of clinical drug trials invokes the Tuskegee Syphilis Study, in which poor black men participated in a research study for 40 years without ever being told they had syphilis. This atrocity led to additional infections and untreated cases of syphilis, and many of the participants died.
That study, and the distrust it helped create, had a significant impact on the participation of African-Americans in clinical drug trials in the 40 years since its end.
Washington describes the ad-hoc group as "a nine-member panel of esteemed professionals whose dissection of the study [Tuskegee Syphilis Study] quickly degenerated into inefficiency, shouting matches, political infighting, accusations of a government cover-up, and the appalling destruction of key evidence.
She exclaims the historian's perspective: "The pertinent issue was not whether the men [the 600 black men experimented on in the 40-year Tuskegee Syphilis Study] had been duly informed of the experiment's danger, but that the men had never been informed that they were in an experiment at all."
In an interview with Dr. Jay Katz, one of the surviving panel members, Sister Washington wrote, "Brandt's work made it painfully clear, says Katz, that the panel had been sabotaged by the gover...
WASHINGTON - American scientists deliberately infected prisoners and patients in a mental hospital in Guatemala with syphilis 60 years ago, a recently unearthed experiment that prompted U.S. officials to apologize Friday and declare outrage over "such reprehensible research.
The discovery dredges up past wrongs in the name of science - like the infamous Tuskegee syphilis study in this country that has long dampened minority participation in medical research - and could complicate ongoing studies overseas that depend on cooperation from some of the world's poorest countries to tackle tough-to-treat diseases.
The Tuskegee Syphilis Study is the most notorious, but there are many others, such as the study at the Willowbrook State School in New York, where mentally retarded children were intentionally infected with the hepatitis A virus in the early 1960s, or the study at the Jewish Chronic Disease Hospital in Brooklyn, where 22 elderly patients were injected with live cancer cells. The subjects emerged looking like concentration-camp victims, but the drama in Tucker's book comes from the psychological effects of starvation: the slow narrowing of desire, the obsession with food, the disturbing dreams of cannibalism.
Those blacks who tried to flee the land were arrested, punished, and returned - or worse - just as their enslaved grandparents would have been," she wrote. "Beatings, lynchings, and murders that were never investigated enforced black serfdom....The only thing blacks had was a great deal of illness. But medical care did not exist for most of them.
"But the PHS lied to the subjects [a pool of infected black men], convincing them that they were being treated, not studied," [Harriet A. Washington] continued. "When the men died, the physician-researchers determined to autopsy them in order to trace precisely the ravages of the disease in their bodies."
By 1943 penicillin, called a "magic bullet," was being dispensed nationally as effective against syphilis, but it was not dispensed to blac...
...Public Health Service launched the "Tuskegee Syphilis Study" involving some 600 sick, dirt-poor...
The notion that the rhetoric espoused by Barack Obama's pastor, the Rev. Jeremiah Wright, mirrors Obama's opinion is ridiculous. The fact this has become such an issue is indicative of guilt-by- association politics. It also ignores the basis of some of Wright's farfetched statements; remember the Tuskegee syphilis study.
In addition, Michelle Obama's now feeling more patriotic ("For the first time in my adult life, I am really proud of my country.") may stem from the fact that her husband is proof that the fundamentals set down by the Constitution are actualities.
We are trying to get people in traditionally underrepresented communities to consider clinical research and what their legal rights are if they participate," said Gerald P. Koocher, Ph.D., dean and professor of the School for Health Sciences at Simmons College. "One of the problems stems from the 1970s when the majority of participants were white males. Today researchers are required by law to include more women and minorities in their studies.
Koocher said he attributes the racial gap in clinical testing in part to blacks' historic distrust of the U.S. health care system. For many, that leeriness stems from the Tuskegee syphilis study, one of the best-known examples of unethical clinical research experimentation in the 20th century.
"There are much more protections against unethical ...
The fact of the matter is, scientific racism is at heart of Black reluctance to accept invitations to seek help from the medical apparatus in these United States. To many Blacks, it's more like governmental United Stakes, manipulated by the health scare system, poised to impale African Americans of all ages. Blacks understandably have a sense of cultural mistrust in the ruthless health scare system that they have endured throughout American history. Additionally, the fact that African Americans are underrepresented when it comes to medical research is at least in part attributable to the fact that "clinical trials" is nothing more than a code phrase for "medical experiments." Could this be an overstatement? Am I perhaps being melodramatic in my assessment? I think not. Note what one aut...
... in the infamous mistreatment of the Tuskegee syphilis study subjects. Maltreatment persisted in...
...Public Health Service Syphilis Study at Tuskegee, Alabama (Syphilis Study) are no...