Clinical trials conducted over three decades in the process of gaining FDA approval for fluoroquinolones-which encompass dozens of antibiotics with "flox" or "ox" in the generic name-showed that psychiatric and central-nervous-system problems occurred in more than 10 percent of patients. Such trials, as well as "adverse drug reaction" (ADR) reports that began to be filed by U.S. doctors and patients once the drugs were being marketed, indicate serious reactions in about 1 to 2 percent of cases in which the drugs are administered. In their practices, doctors often appear to blame other factors for damage done by the drugs. Says [Jay Cohen], "Unfortunately, many doctors do not know that fluoroquinolones can cause such severe, long-lasting reactions. When a reaction occurs, some doctors de...
Mark & Associates and The Lanier Law Firm have filed three lawsuits in state court in New Jersey against the makers of Levaquin, alleging the antibiotic caused tendon ruptures. According to a press release, the suits allege than Johnson & Johnson and Ortho-McNeil promoted Levaquin as a safe and effective treatment for bacterial infections of the lungs, sinus, skin and urinary tract. The plaintiffs - from Indiana, Massachusetts and New Jersey - also allege that the companies knew for years that Levaquin - one of a class of drugs known as fluoroquinolones, had caused severe tendon ruptures and tendonitis at a higher rate than other antibiotics.
DEAR DR. DONOHUE: A little more than a month ago, I was hospitalized for pneumonia. I spent a full week in the hospital, taking antibiotics. I was still taking them when I went home. That's when I developed diarrhea. My doctor told me to stop the antibiotics, and I did. The diarrhea continued, and I had to be readmitted to the hospital. They put me on a different antibiotic. I think I'm OK now, but I wonder about all this. What exactly went wrong? -- D.P. ANSWER: You had antibiotic-associated colitis, the cause of which is a bacterium by the name of C. difficile. It happens like this: People take an antibiotic for an infection, like your pneumonia. The antibiotic is somewhat indiscriminate in killing off bacteria. In this instance, it kills off the good bacteria in the colon, the ones t...
...(10) Fluoroquinolones; and. (11) Glycopeptides. (12) Phenylbutazone in f...
WASHINGTON, Jan. 4, 2012 /PRNewswire-USNewswire/ -- The Pew Campaign on Human Health and Industrial Farming today praised the U.S. Food and Drug Administration (FDA) for limiting the use of cephalosporins in food animal production. Cephalosporins are vital treatments for children suffering from infection; unlike other antibiotics, such as fluoroquinolones and tetracyclines, they carry no warnings or precautions for pediatric use. They also are important medicines for treating people suffering from bacterial meningitis and infections of the bone, urinary tract, and upper respiratory system, as well as those associated with cancer.
The consumer group Public Citizen asked the FDA in 2006 to put a black-box warning on Cipro and other fluoroquinolones. According to the FDA, fluoroquinolones can increase the risk of tendon inflammation and rupture from 1 in 100,000 patients to 3 or 4 in 100,000 patients. But this increased risk is miniscule when you consider the number of lives Levaquin or Cipro save in patients with pneumonia, infectious colitis or serious urinary tract infections. Medications should be prescribed on a case-by-case basis and should be based on reason rather than emotion.
Several major U.S. poultry corporations have stated they no longer use fluoroquinolones to produce chicken for human consumption. Many leading food-service companies -- including McDonald's, Dairy Queen, Burger King, Domino's, Hardee's, Wendy's, Popeye's, Subway, and Bon Appetit -- also have stated that they do not purchase chicken raised with these drugs. In addition, pending legislation would ban the national school lunch program from serving chicken that was produced with the use of fluoroquinolones. ------
WASHINGTON, Sept. 7 /U.S. Newswire/ -- The Keep Antibiotics Working (KAW) coalition commended the Bayer Corp. for its decision today to end its five-year battle against efforts by the U.S. Food and Drug Administration (FDA) to ban the use in poultry of Baytril, an antibiotic that is nearly identical to the key human-use antibiotic Cipro. The FDA originally proposed banning poultry- Baytril in October 2000. On July 28, 2005, FDA Commissioner Dr. Lester Crawford issued the FDA's final decision (see http:// www.fda.gov/bbs/topics/news/2005/new01212.html ), marking the agency's first-ever decision to curtail use of an agricultural antibiotic because of concerns about antibiotic resistance affecting humans. On August 26, Bayer, the Animal Health Institute (an agricultural drug trade group)...
... their suppliers to stop using fluoroquinolones in chicken. Many major medical groups, including ...
Fluoroquinolones - Brief Article
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